Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 20/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18133352 | 0.94 | S1PR5 (0.50) | S1PR5S1PR1S1PR3 | |
| SCHEMBL326292 | 0.89 | S1PR5 (0.51) | S1PR5S1PR1S1PR3 | |
| SCHEMBL10264814 | 0.89 | S1PR5 (0.48) | S1PR5S1PR1S1PR3 | |
| SCHEMBL15137252 | 0.88 | S1PR5 (0.49) | S1PR5S1PR1S1PR3 | |
| SCHEMBL15144571 | 0.86 | S1PR5 (0.47) | S1PR5S1PR1S1PR3 | |
| SCHEMBL15144624 | 0.83 | S1PR5 (0.59) | S1PR5S1PR1S1PR3 | |
| SCHEMBL325649 | 0.83 | S1PR5 (0.53) | S1PR5S1PR1S1PR3 | |
| SCHEMBL15144587 | 0.83 | S1PR5 (0.53) | S1PR5S1PR1S1PR3 | |
| SCHEMBL326221 | 0.83 | S1PR5 (0.56) | S1PR5S1PR1S1PR3 | |
| SCHEMBL10265427 | 0.83 | S1PR5 (0.56) | S1PR5S1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144312-A1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | AbbVie B.V. (NL) | 2017-03-22 | — | — | EP | disclosed |
| EP-2590955-B9 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBVIE BV (NL) | 2017-02-22 | — | — | EP | disclosed |
| EP-2590955-B1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBVIE BV (NL) | 2016-10-12 | — | — | EP | disclosed |
| WO-2012004378-A1 | SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2012-01-12 | — | — | WO | disclosed |