Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | ROS1 | P08922 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 6/20 | 0.35 |
| ▸ | EHMT1 | Q9H9B1 | 5/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL589081 | 0.90 | MAPT (0.38) | EML4ALKRETROS1FLT3 | |
| SCHEMBL10283434 | 0.90 | PDE4D (0.35) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL194991 | 0.89 | PDE4D (0.35) | EML4ALKRETROS1FLT3 | |
| SCHEMBL12879550 | 0.89 | ACACB (0.33) | EML4ALKRETROS1FLT3 | |
| SCHEMBL12879569 | 0.89 | PDE4D (0.33) | EML4ALKRETROS1FLT3 | |
| SCHEMBL12921314 | 0.87 | PDE4D (0.36) | PDE4DEHMT2EHMT1TNF | |
| SCHEMBL12872258 | 0.87 | SMN1; SMN2 (0.36) | EML4ALKLMNASMN1; SMN2RET | |
| SCHEMBL12879584 | 0.87 | IRAK4 (0.33) | PDE4DALOX5EPHX2EHMT2EHMT1 | |
| SCHEMBL12921374 | 0.86 | PDE4D (0.34) | LMNACYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL12887076 | 0.86 | AKR1C3 (0.38) | EML4ALKRETROS1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8114878-B2 | 6,7-dihydrothieno[3,2-d]pyrimidine for the treatment of inflammatory diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-14 | — | — | US | disclosed |