Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 14/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573309 | 0.93 | ALK (0.41) | ALKSPRNTRK1INSRLCK | |
| SCHEMBL573311 | 0.93 | ALK (0.41) | ALKSPRNTRK1INSRLCK | |
| SCHEMBL573310 | 0.93 | ALK (0.41) | ALKSPRNTRK1INSRLCK | |
| SCHEMBL572454 | 0.92 | ALK (0.51) | ALKNTRK1INSRLCKLTK | |
| SCHEMBL572455 | 0.92 | ALK (0.51) | ALKNTRK1INSRLCKLTK | |
| SCHEMBL572456 | 0.92 | ALK (0.51) | ALKNTRK1INSRLCKLTK | |
| SCHEMBL572822 | 0.90 | ALK (0.52) | ALKSPRNTRK1INSRLCK | |
| SCHEMBL572819 | 0.90 | ALK (0.52) | ALKSPRNTRK1INSRLCK | |
| SCHEMBL572820 | 0.90 | ALK (0.52) | ALKSPRNTRK1INSRLCK | |
| SCHEMBL572821 | 0.90 | ALK (0.52) | ALKSPRNTRK1INSRLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012018668-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |