Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.78 |
| ▸ | APP | P05067 | 15/20 | 0.78 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18927185 | 0.88 | BACE1 (1.00) | BACE1APP | |
| SCHEMBL9948882 | 0.88 | BACE1 (1.00) | BACE1APP | |
| SCHEMBL9948883 | 0.88 | BACE1 (1.00) | BACE1APP | |
| SCHEMBL21654465 | 0.87 | BACE1 (0.70) | BACE1APPTHRBPKMRXFP1 | |
| SCHEMBL9948594 | 0.82 | BACE1 (0.89) | BACE1APP | |
| SCHEMBL19566705 | 0.81 | BACE1 (0.77) | BACE1APP | |
| SCHEMBL18926487 | 0.70 | BACE1 (0.65) | BACE1APP | |
| SCHEMBL9948169 | 0.70 | BACE1 (1.00) | BACE1APP | |
| SCHEMBL9948016 | 0.70 | BACE1 (1.00) | BACE1APP | |
| SCHEMBL18926458 | 0.69 | BACE1 (0.68) | BACE1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087237-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |