Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.45 |
| ▸ | FYN | P06241 | 4/20 | 0.37 |
| ▸ | SYK | P43405 | 6/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | FER | P16591 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | BLK | P51451 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10270160 | 0.92 | MAP4K2 (0.54) | MAP4K2FYNSYKMAP4K4PKN2 | |
| SCHEMBL10270290 | 0.87 | MAP4K2 (0.40) | MAP4K2SYKMAP4K4PKN2AURKB | |
| SCHEMBL12680505 | 0.87 | MAP4K2 (0.41) | MAP4K2FYNSYKMAP4K4PKN2 | |
| SCHEMBL10269928 | 0.85 | HRH4 (0.48) | MAP4K2FYNSYKMAP4K4PKN2 | |
| SCHEMBL10270292 | 0.84 | SYK (0.39) | MAP4K2SYKMAP4K4PKN2AURKB | |
| SCHEMBL10270176 | 0.83 | SYK (0.41) | MAP4K2FYNSYKKDRCDK2 | |
| SCHEMBL14079553 | 0.82 | TYRO3 (0.44) | FYNJAK2CLK4CYP3A4 | |
| SCHEMBL10270295 | 0.81 | PIM1 (0.41) | MAP4K2SYKMAP4K4PKN2AURKB | |
| SCHEMBL10270304 | 0.81 | SYK (0.36) | MAP4K2FYNSYKMAP4K4PKN2 | |
| SCHEMBL10270293 | 0.80 | SCN5A (0.37) | MAP4K2SYKMAP4K4PKN2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137188-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Pharma AG (DE) | 2012-06-06 | — | — | EP | disclosed |
| WO-2008113469-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-25 | — | — | WO | disclosed |