Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.80 |
| ▸ | APP | P05067 | 16/20 | 0.75 |
| ▸ | CTSD | P07339 | 1/20 | 0.60 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18562844 | 0.89 | BACE1 (1.00) | BACE1APPCTSDBACE2 | |
| SCHEMBL10250306 | 0.89 | BACE1 (1.00) | BACE1APPCTSDBACE2 | |
| SCHEMBL9947826 | 0.89 | BACE1 (1.00) | BACE1APPCTSDBACE2 | |
| SCHEMBL9947830 | 0.89 | BACE1 (1.00) | BACE1APPCTSDBACE2 | |
| SCHEMBL10271132 | 0.88 | BACE1 (0.80) | BACE1APPCTSDBACE2 | |
| SCHEMBL10270834 | 0.87 | BACE1 (0.81) | BACE1APPCTSDBACE2 | |
| SCHEMBL10271125 | 0.85 | BACE1 (1.00) | BACE1APPCTSDBACE2 | |
| SCHEMBL9948570 | 0.85 | BACE1 (1.00) | BACE1APPCTSDBACE2 | |
| SCHEMBL10270982 | 0.85 | BACE1 (1.00) | BACE1APPCTSDBACE2 | |
| SCHEMBL9948336 | 0.85 | BACE1 (1.00) | BACE1APPCTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012087237-A1 | COMPOUNDS AND THEIR USE AS BACE INHIBITORS | ASTRAZENECA AB (SE) | 2012-06-28 | — | — | WO | disclosed |