Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15099627 | 0.91 | HTT (0.37) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL10271806 | 0.89 | HTT (0.36) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL1699546 | 0.89 | HTT (0.36) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL15099754 | 0.89 | HTT (0.38) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL15165315 | 0.88 | MAPT (0.35) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL1699726 | 0.88 | MAPT (0.35) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL10271807 | 0.87 | MAPT (0.35) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL10271719 | 0.85 | HTT (0.38) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL15099676 | 0.83 | MAPT (0.34) | HTTMAPTSMN1; SMN2HSD17B10ATM | |
| SCHEMBL15099642 | 0.83 | HTT (0.35) | HTTMAPTSMN1; SMN2HSD17B10ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |