Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.41 |
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2718415 | 0.84 | CA12 (0.41) | CA1CA2CA12CA9STK17B | |
| SCHEMBL2716329 | 0.76 | ITK (0.45) | CA1CA2CA12CA9NPSR1 | |
| SCHEMBL2717865 | 0.72 | CA12 (0.39) | CA1CA2CA12CA9STK17B | |
| SCHEMBL22847628 | 0.66 | CA12 (0.38) | CA1CA2CA12CA9NPSR1 | |
| SCHEMBL20283057 | 0.66 | CA1 (0.48) | CA1CA2CA12CA9STK17B | |
| SCHEMBL17563718 | 0.65 | ADORA2A (0.43) | STK17BSTK17AMAOAMAOBMEN1 | |
| SCHEMBL24936290 | 0.65 | STK17B (0.46) | CA1CA2CA12CA9STK17B | |
| SCHEMBL30522690 | 0.65 | STK17B (0.46) | CA1CA2CA12CA9STK17B | |
| SCHEMBL2718598 | 0.65 | MEN1 (0.38) | MEN1KMT2A | |
| SCHEMBL17563559 | 0.65 | BCHE (0.44) | STK17BSTK17ANPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |