Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271831 | 0.90 | SYK (0.50) | SYKCDK5CCNA2CDK2CDK5R1 | |
| SCHEMBL10271911 | 0.88 | SYK (0.54) | SYKCDK1CSNK1A1CDK5CCNT1 | |
| SCHEMBL10272160 | 0.88 | SYK (0.44) | SYKCDK1CSNK1A1CDK5CCNT1 | |
| SCHEMBL2718542 | 0.87 | SYK (0.44) | SYKCDK1CSNK1A1CDK5CCNT1 | |
| SCHEMBL2728255 | 0.85 | SYK (0.47) | SYKCDK1CSNK1A1CDK5CCNT1 | |
| SCHEMBL2728248 | 0.85 | SYK (0.47) | SYKCDK1CSNK1A1CDK5CCNT1 | |
| SCHEMBL10272159 | 0.83 | SYK (0.59) | SYK | |
| SCHEMBL2729206 | 0.83 | SYK (0.47) | SYKCDK1CSNK1A1CDK5CCNT1 | |
| SCHEMBL2729199 | 0.83 | SYK (0.47) | SYKCDK1CSNK1A1CDK5CCNT1 | |
| SCHEMBL10271839 | 0.81 | SYK (0.49) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |