Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | LCK | P06239 | 2/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.32 |
| ▸ | SYK | P43405 | 5/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19901787 | 1.00 | BTK (0.33) | BTKJAK3LCKMAP2K2MAP2K1 | |
| SCHEMBL9109019 | 0.92 | SYK (0.35) | BTKJAK3LCKMAP2K2MAP2K1 | |
| SCHEMBL9109057 | 0.92 | SYK (0.35) | BTKJAK3LCKMAP2K2MAP2K1 | |
| SCHEMBL2716898 | 0.88 | SYK (0.40) | SYK | |
| SCHEMBL2716876 | 0.88 | SYK (0.40) | SYK | |
| SCHEMBL2729967 | 0.87 | MAP2K2 (0.32) | MAP2K2MAP2K1SYKTNFIRAK4 | |
| SCHEMBL2729975 | 0.87 | MAP2K2 (0.32) | MAP2K2MAP2K1SYKTNFIRAK4 | |
| SCHEMBL2729140 | 0.87 | SYK (0.35) | BTKJAK3LCKMAP2K2MAP2K1 | |
| SCHEMBL2715508 | 0.85 | BTK (0.33) | BTKJAK3LCKMAP2K2MAP2K1 | |
| SCHEMBL2715519 | 0.85 | BTK (0.33) | BTKJAK3LCKMAP2K2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |