Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | YES1 | P07947 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | FGR | P09769 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | PRKCA | P17252 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.58 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.58 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.58 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714029 | 1.00 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL2726896 | 0.90 | SYK (0.76) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL14929575 | 0.89 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL9110112 | 0.89 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL14908938 | 0.89 | SYK (0.75) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL2713074 | 0.87 | SYK (0.78) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL1354024 | 0.86 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL2627324 | 0.86 | SYK (1.00) | SYKKCNH2JAK2LCKYES1 | |
| SCHEMBL2712734 | 0.85 | SYK (0.59) | SYKKCNH2JAK2LCKLYN | |
| SCHEMBL2715340 | 0.85 | SYK (0.73) | SYKKCNH2JAK2LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |