Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL897265 | 0.90 | ALK (0.83) | ALK | |
| SCHEMBL20004126 | 0.88 | ALK (0.78) | ALK | |
| SCHEMBL896989 | 0.87 | ALK (0.77) | ALK | |
| SCHEMBL897337 | 0.87 | ALK (0.82) | ALK | |
| SCHEMBL897303 | 0.87 | ALK (0.80) | ALK | |
| SCHEMBL897227 | 0.86 | ALK (1.00) | ALKIGF1RSRCKDR | |
| SCHEMBL897215 | 0.85 | ALK (0.83) | ALKIGF1RSRCKDR | |
| SCHEMBL896658 | 0.85 | ALK (1.00) | ALK | |
| SCHEMBL897117 | 0.85 | ALK (0.85) | ALK | |
| SCHEMBL20004582 | 0.84 | ALK (0.60) | ALKABL1INSRIGF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |