Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.59 |
| ▸ | KDR | P35968 | 14/20 | 0.57 |
| ▸ | FLT1 | P17948 | 7/20 | 0.57 |
| ▸ | FLT3 | P36888 | 7/20 | 0.57 |
| ▸ | KIT | P10721 | 7/20 | 0.57 |
| ▸ | CSF1R | P07333 | 5/20 | 0.57 |
| ▸ | TEK | Q02763 | 5/20 | 0.57 |
| ▸ | FLT4 | P35916 | 5/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.57 |
| ▸ | LCK | P06239 | 4/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | FRK | P42685 | 3/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL327929 | 0.92 | FLT3 (0.57) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL328034 | 0.91 | KDR (0.55) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL328075 | 0.91 | KDR (0.56) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL10273031 | 0.90 | KDR (0.54) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL328021 | 0.89 | KDR (0.53) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL276060 | 0.88 | FLT3 (0.68) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL9979872 | 0.87 | KDR (0.54) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL328052 | 0.86 | FLT3 (0.65) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL10273834 | 0.86 | KDR (0.55) | AURKAAURKBKDRFLT1FLT3 | |
| SCHEMBL10291315 | 0.86 | FLT3 (0.64) | AURKAAURKBKDRFLT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165314-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165314-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | CDK4, FLT4, CDKL4 | AURKA 1123/4885AURKB 1695/4885KDR 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.