Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | GALR3 | O60755 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL750351 | 0.84 | USP7 (0.34) | MAPTTACR1USP7TP53ALDH1A1 | |
| SCHEMBL12714509 | 0.79 | TP53 (0.33) | MAPTTACR1USP7TP53ALDH1A1 | |
| SCHEMBL750140 | 0.77 | MAPT (0.35) | MAPTTACR1USP7TP53ALDH1A1 | |
| SCHEMBL751631 | 0.75 | TACR1 (0.36) | MAPTTACR1USP7TP53ALDH1A1 | |
| SCHEMBL752271 | 0.72 | DYRK1B (0.40) | MAPTUSP7ALDH1A1SMN1; SMN2GALR3 | |
| SCHEMBL751894 | 0.70 | USP7 (0.38) | MAPTTACR1USP7TP53ALDH1A1 | |
| SCHEMBL752508 | 0.70 | RIPK3 (0.46) | MAPTTACR1USP7ALDH1A1SMN1; SMN2 | |
| SCHEMBL750203 | 0.67 | GRIN1 (0.40) | ALDH1A1SMN1; SMN2GALR3RAB9ATSHR | |
| SCHEMBL753472 | 0.67 | RIPK3 (0.39) | MAPTTACR1USP7TSHRGRIN1 | |
| SCHEMBL749861 | 0.67 | TSHR (0.37) | MAPTTACR1USP7ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439174-B1 | 4-IMIDAZOLIN-2-ONE COMPOUNDS AS p38 MAP KINASE INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-21 | — | — | EP | disclosed |