Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.46 |
| ▸ | FRK | P42685 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.46 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.46 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 11/20 | 0.40 |
| ▸ | KIT | P10721 | 7/20 | 0.40 |
| ▸ | TEK | Q02763 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10272915 | 0.93 | FLT3 (0.52) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL276297 | 0.90 | FLT3 (0.57) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL277539 | 0.85 | FLT3 (0.57) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL275264 | 0.83 | FLT3 (0.65) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL10290555 | 0.82 | FLT3 (0.44) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL275731 | 0.81 | FGFR1 (0.54) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL277308 | 0.81 | FGFR1 (0.54) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL327888 | 0.80 | FLT3 (0.60) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL276622 | 0.77 | FGFR1 (0.74) | FLT3FGFR1RPS6KA3MAPK9RET | |
| SCHEMBL10291315 | 0.77 | FLT3 (0.64) | FLT3FGFR1RPS6KA3MAPK9RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165314-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165314-A1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | CDK4, FLT4, CDKL4 | FLT3 318/4885FGFR1 19/4885RPS6KA3 829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.