Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12955997 | 1.00 | F10 (0.61) | F10KCNH2JAK2JAK1TYK2 | |
| SCHEMBL8262273 | 1.00 | F10 (0.61) | F10KCNH2JAK2JAK1TYK2 | |
| SCHEMBL1030634 | 0.96 | F10 (0.58) | F10KCNH2JAK2JAK1TYK2 | |
| SCHEMBL1029306 | 0.85 | F10 (0.52) | F10KCNH2JAK2JAK1TYK2 | |
| SCHEMBL8261113 | 0.85 | F10 (0.52) | F10KCNH2JAK2JAK1TYK2 | |
| SCHEMBL4709195 | 0.84 | F10 (0.56) | F10JAK2JAK1TYK2JAK3 | |
| SCHEMBL1029183 | 0.82 | F10 (0.57) | F10 | |
| SCHEMBL8241630 | 0.82 | F10 (0.56) | F10KCNH2JAK2JAK1TYK2 | |
| SCHEMBL8261185 | 0.81 | F10 (0.61) | F10 | |
| SCHEMBL4599427 | 0.80 | F10 (0.49) | F10KCNH2JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814855-B1 | DICARBOXAMIDE DERIVATIVES AND THEIR USE AS FACTOR XA INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-01-19 | — | — | EP | disclosed |