Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amprenavir. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CTSD | P07339 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP3A5 | P20815 | 1/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 1.00 |
| ▸ | TBXAS1 | P24557 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.72 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.72 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.72 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amprenavir SCHEMBL7287657 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL11914014 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL1388821 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL20099148 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL5551513 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL3174937 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL34151 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL2671137 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL20451345 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 | |
| Amprenavir SCHEMBL12647024 | 1.00 | MLNR (1.00) | MLNRABCB11LMNACTSDCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046062-A1 | USE OF PRODRUGS TO AVOID GI MEDIATED ADVERSE EVENTS | SHIRE, LLC (US) | 2012-04-12 | — | — | WO | disclosed |