Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | TYK2 | P29597 | 1/20 | 0.61 |
| ▸ | KIT | P10721 | 5/20 | 0.59 |
| ▸ | AKT1 | P31749 | 5/20 | 0.59 |
| ▸ | AKT2 | P31751 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323706 | 0.86 | JAK3 (0.78) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL323969 | 0.86 | JAK3 (0.66) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL1045883 | 0.84 | JAK3 (0.84) | JAK3JAK2LCK | |
| SCHEMBL2778397 | 0.84 | JAK3 (0.63) | JAK3JAK2JAK1TYK2KIT | |
| SCHEMBL323307 | 0.84 | JAK3 (0.60) | JAK3JAK2JAK1TYK2KIT | |
| SCHEMBL10277501 | 0.82 | AKT1 (0.50) | JAK3JAK2JAK1TYK2AKT1 | |
| SCHEMBL323604 | 0.81 | JAK3 (0.88) | JAK3JAK2LCK | |
| SCHEMBL1049868 | 0.81 | JAK3 (0.81) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL20411223 | 0.80 | JAK3 (0.69) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL12547685 | 0.80 | JAK3 (1.00) | JAK3JAK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346809-B2 | Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors | LEO PHARMA A/S (DK) | 2016-05-24 | — | — | US | claimed |
| CN-102574857-B | Heterocyclic compounds as jak receptor and protein tyrosine kinase inhibitors | LEO PHARMA AS | 2015-06-10 | — | — | CN | claimed |
| EP-2451813-B1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA AS (DK) | 2014-10-01 | — | — | EP | claimed |
| US-20120178740-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2012-07-12 | — | — | US | claimed |
| US-9346809-B2 | Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors | LEO PHARMA A/S (DK) | 2016-05-24 | — | — | US | disclosed |
| US-20120178740-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178740-A1 | HETEROCYCLIC COMPOUNDS AS JAK RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | JAK1, JAK2, JAK3 | JAK3 3/4885JAK2 2/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.