Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 9/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 10/20 | 0.38 |
| ▸ | PIM1 | P11309 | 9/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14906181 | 0.87 | PIM2 (0.41) | PIM3PIM2PIM1 | |
| SCHEMBL10278515 | 0.85 | PIM1 (0.42) | PIM3PIM2PIM1 | |
| SCHEMBL14891214 | 0.73 | PIM1 (0.44) | PIM3PIM2PIM1 | |
| SCHEMBL1911224 | 0.72 | PIM1 (0.47) | PIM3PIM2PIM1 | |
| SCHEMBL14906165 | 0.68 | PIM1 (0.62) | PIM3PIM2PIM1 | |
| SCHEMBL14906208 | 0.64 | PIM1 (0.69) | PIM3PIM2PIM1GSK3B | |
| SCHEMBL14906105 | 0.64 | PIM1 (0.69) | PIM3PIM2PIM1GSK3B | |
| SCHEMBL1911159 | 0.63 | PIM1 (0.64) | PIM3PIM2PIM1GSK3B | |
| SCHEMBL14892242 | 0.63 | CRBN (0.46) | CD38CYP2D6CYP2B6CYP2C19 | |
| SCHEMBL14906182 | 0.62 | PIM2 (0.59) | PIM3PIM2PIM1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |