Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 18/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 18/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1910901 | 0.88 | CYP3A4 (0.60) | CYP3A4CYP2D6CYP2C9PIM1PIM3 | |
| SCHEMBL10278603 | 0.86 | CYP3A4 (0.49) | CYP3A4CYP2D6CYP2C9PIM1PIM3 | |
| SCHEMBL1910923 | 0.83 | CYP3A4 (0.60) | CYP3A4CYP2D6CYP2C9PIM1PIM3 | |
| SCHEMBL14906141 | 0.82 | CYP3A4 (0.51) | CYP3A4CYP2D6CYP2C9PIM1PIM3 | |
| SCHEMBL1911136 | 0.81 | CYP3A4 (0.59) | CYP3A4CYP2D6CYP2C9PIM1PIM3 | |
| SCHEMBL14906190 | 0.81 | CYP3A4 (0.59) | CYP3A4CYP2D6CYP2C9PIM1PIM3 | |
| SCHEMBL1910903 | 0.81 | CYP3A4 (0.58) | CYP3A4CYP2D6CYP2C9PIM1PIM3 | |
| SCHEMBL14892033 | 0.80 | DYRK1A (0.53) | CYP3A4PIM2GSK3BDYRK1A | |
| SCHEMBL10278811 | 0.80 | PIM3 (0.64) | PIM1PIM3PIM2 | |
| SCHEMBL1911137 | 0.80 | PIM1 (0.45) | PIM1PIM3PIM2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130109682-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-05-02 | — | — | US | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109682-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | PIM1, GSK3A, GSK3B | CYP3A4 1642/4885CYP2D6 2526/4885CYP2C9 1937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.