Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.44 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 9/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10278705 | 0.96 | HSP90AA1 (0.45) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL10278707 | 0.90 | HSP90AA1 (0.41) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL501334 | 0.90 | HSP90AA1 (0.48) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL10278747 | 0.89 | HSP90AA1 (0.47) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL500811 | 0.88 | HSP90AA1 (0.51) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL10278215 | 0.85 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1HDAC3HDAC4HDAC1 | |
| SCHEMBL1863722 | 0.85 | HSP90AA1 (0.48) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL28130338 | 0.84 | HSP90AA1 (0.59) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL500899 | 0.84 | HSP90AA1 (0.43) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 | |
| SCHEMBL501115 | 0.84 | HSP90AA1 (0.43) | HSP90AA1HSP90B1TRAP1HSP90AB1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106083-B2 | Triazole compounds that modulate HSP90 activity | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20100113447-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113447-A1 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90B1 2/4885TRAP1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.