Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18023089 | 0.94 | UGT1A1 (0.38) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL368500 | 0.78 | UGT1A1 (0.51) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL369277 | 0.71 | UGT1A1 (0.52) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL10324544 | 0.70 | UGT1A1 (0.32) | UGT1A1KCNH2SLCO1B1 | |
| SCHEMBL369543 | 0.67 | UGT1A1 (0.48) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL10324958 | 0.66 | UGT1A1 (0.35) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL10324462 | 0.66 | UGT1A1 (0.33) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL369451 | 0.66 | UGT1A1 (0.48) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL1225620 | 0.62 | UGT1A1 (0.53) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL18023082 | 0.62 | UGT1A1 (0.54) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009309-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-01-19 | — | — | WO | disclosed |