Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 20/20 | 1.00 |
| ▸ | IRAK1 | P51617 | 9/20 | 1.00 |
| ▸ | SYK | P43405 | 7/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 0.75 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.75 |
| ▸ | FLT3 | P36888 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19265933 | 1.00 | IRAK4 (1.00) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| SCHEMBL10254038 | 1.00 | IRAK4 (1.00) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| SCHEMBL10254407 | 1.00 | IRAK4 (1.00) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| Hydrochloric Acid SCHEMBL359133 | 0.99 | IRAK4 (0.98) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| Hydrochloric Acid SCHEMBL358125 | 0.99 | IRAK4 (0.98) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| Hydrochloric Acid SCHEMBL358360 | 0.99 | IRAK4 (0.98) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| SCHEMBL10258448 | 0.97 | IRAK4 (1.00) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| SCHEMBL358424 | 0.97 | IRAK4 (1.00) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| SCHEMBL10253920 | 0.97 | IRAK4 (1.00) | IRAK4IRAK1SYKAURKAMAP3K7 | |
| Hydrochloric Acid SCHEMBL358979 | 0.96 | IRAK4 (0.98) | IRAK4IRAK1SYKAURKAMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007375-A1 | PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |