SCHEMBL10281175

SCHEMBL10281175

Cn1c(-c2ccccc2S(=O)(=O)CC(F)(F)F)nc2cc(C(F)(F)F)cnc21

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.42
PDE2A O00408 1/20 0.41
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
USP1 O94782 2/20 0.36
KMT2A Q03164 2/20 0.35
ALOX5AP P20292 1/20 0.34
PTGS2 P35354 6/20 0.33
DDR1 Q08345 1/20 0.33
HSD11B1 P28845 1/20 0.33
HSD11B2 P80365 1/20 0.33
MEN1 O00255 1/20 0.33
PTGS1 P23219 1/20 0.33
HCRTR1 O43613 1/20 0.32
HCRTR2 O43614 1/20 0.32
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15412012 0.92 POLB (0.46) POLBPDE2ALMNAHTTUSP1
SCHEMBL15427220 0.89 POLB (0.44) POLBPDE2ALMNAHTTUSP1
SCHEMBL15412428 0.88 POLB (0.41) POLBPDE2ALMNAHTTUSP1
SCHEMBL15412816 0.87 PDE2A (0.53) POLBPDE2ALMNAHTTUSP1
SCHEMBL15412730 0.86 PDE2A (0.42) POLBPDE2ALMNAHTTKMT2A
SCHEMBL15412795 0.86 PDE2A (0.43) POLBPDE2ALMNAHTTKMT2A
SCHEMBL15412928 0.86 PDE2A (0.43) POLBPDE2ALMNAHTTKMT2A
SCHEMBL10281048 0.83 POLB (0.38) POLBPDE2ALMNAHTTUSP1
SCHEMBL10280722 0.82 POLB (0.37) POLBPDE2ALMNAHTTUSP1
SCHEMBL17824504 0.81 POLB (0.45) POLBPDE2ALMNAHTTUSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006429-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2019-02-06 EP disclosed
EP-2655337-B1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL CO (JP) 2016-11-23 EP disclosed
US-9278983-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-03-08 US disclosed
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-12-11 US disclosed
US-8853238-B2 Fused heterocyclic compound and use thereof for pest control SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-10-07 US disclosed
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed
WO-2012086848-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-06-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140018373-A1 FUSED HETEROCYCLIC COMPOUND AND USE FOR PEST CONTROL THEREOF NR4A1, NR2C2, NR0B1 POLB 4715/4885PDE2A 3467/4885LMNA 1591/4885
US-20140364444-A1 FUSED HETEROCYCLIC COMPOUND AND USE THEREOF FOR PEST CONTROL NR4A1, NR2C2, NR0B1 POLB 4737/4885PDE2A 3420/4885LMNA 1629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.