Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 13/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17450214 | 0.90 | MELK (0.54) | MELKKDM4EMEN1GAAKMT2A | |
| SCHEMBL531690 | 0.88 | KMT2A (0.60) | KDM4EMEN1GAAKMT2A | |
| SCHEMBL10282212 | 0.85 | MELK (0.50) | MELKKDM4EMEN1GAAKMT2A | |
| SCHEMBL10281816 | 0.77 | KMT2A (0.61) | KDM4EMEN1GAAKMT2A | |
| SCHEMBL10282434 | 0.77 | MELK (0.68) | MELK | |
| SCHEMBL10282213 | 0.77 | MELK (0.77) | MELK | |
| SCHEMBL529115 | 0.77 | MELK (0.51) | MELKKDM4EMEN1GAAKMT2A | |
| SCHEMBL10282210 | 0.76 | MAPT (0.50) | KDM4EMEN1GAAKMT2AATM | |
| SCHEMBL530888 | 0.76 | KCNH2 (0.54) | MELKKDM4EMEN1GAAKMT2A | |
| Hydrochloric Acid SCHEMBL529682 | 0.75 | MAPT (0.49) | KDM4EMEN1GAAKMT2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |