Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2693804 | 0.87 | CSF1R (0.56) | CSF1RMEN1KMT2ASYKMAPK9 | |
| SCHEMBL2694558 | 0.83 | AKR1C3 (0.55) | CSF1RMEN1KMT2ASYKIRAK4 | |
| SCHEMBL2696618 | 0.80 | CSF1R (0.49) | CSF1RMEN1KMT2ASYKRAB9A | |
| SCHEMBL2696622 | 0.78 | JAK3 (0.59) | CSF1RIRAK4JAK2JAK1TYK2 | |
| SCHEMBL2694919 | 0.78 | CSF1R (0.47) | CSF1RMEN1KMT2ASYKRAB9A | |
| SCHEMBL2479684 | 0.78 | JAK3 (0.79) | CSF1RMEN1KMT2AIRAK4JAK2 | |
| SCHEMBL2694923 | 0.77 | JAK3 (0.61) | CSF1RMEN1KMT2AIRAK4JAK2 | |
| SCHEMBL17452163 | 0.77 | IRAK4 (0.62) | CSF1RMEN1KMT2ASYKRAB9A | |
| SCHEMBL2696458 | 0.77 | JAK3 (0.52) | CSF1RSYKIRAK4JAK2JAK1 | |
| SCHEMBL2694880 | 0.76 | JAK3 (0.56) | CSF1RMAPK10IRAK4JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |