Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.42 |
| ▸ | CTSD | P07339 | 3/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10285710 | 0.66 | BACE1 (0.51) | BACE1CTSD | |
| SCHEMBL10285133 | 0.65 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL10285408 | 0.65 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL10285424 | 0.65 | BACE1 (0.56) | BACE1CTSD | |
| SCHEMBL570770 | 0.64 | BACE1 (0.51) | BACE1 | |
| SCHEMBL570684 | 0.64 | BACE1 (0.51) | BACE1 | |
| SCHEMBL570867 | 0.64 | BACE1 (0.51) | BACE1 | |
| SCHEMBL10285111 | 0.62 | BACE1 (0.59) | BACE1 | |
| SCHEMBL10285496 | 0.62 | BACE1 (0.59) | BACE1 | |
| SCHEMBL570820 | 0.62 | BACE1 (0.59) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019056-A1 | AMINO-ISO-INDOLE, AMINO-AZA-ISO-INDOLE, AMINO-DIHYDROISOQUINOLINE AND AMINO-BENZOXAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2012-02-09 | — | — | WO | disclosed |