Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4174028 | 0.89 | CLK4 (0.36) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL10286347 | 0.88 | PIK3CD (0.52) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL4177698 | 0.85 | CLK4 (0.36) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL12015594 | 0.85 | PIK3CD (0.49) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL12015593 | 0.84 | PIK3CD (0.48) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL10286281 | 0.84 | PIK3CD (0.54) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL14850585 | 0.82 | PIK3CD (0.48) | PIK3CDMAPK1MAPTRAB9A | |
| SCHEMBL4173738 | 0.80 | PIK3CD (0.47) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL4173852 | 0.79 | PIK3CD (0.38) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 | |
| SCHEMBL19788583 | 0.78 | PIK3CD (0.39) | PIK3CDCYP2D6CYP3A4TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193199-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20090137581-A1 | Heterocyclic compounds and their uses | AMGEN INC. | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137581-A1 | Heterocyclic compounds and their uses | MCL1, BCL9, MALT1 | PIK3CD 16/4885CYP2D6 2966/4885CYP3A4 3267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.