Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.57 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.57 |
| ▸ | JAK2 | O60674 | 5/20 | 0.57 |
| ▸ | JAK1 | P23458 | 5/20 | 0.57 |
| ▸ | TYK2 | P29597 | 5/20 | 0.57 |
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2697553 | 0.92 | JAK3 (0.54) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2695814 | 0.90 | JAK3 (0.52) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2693436 | 0.90 | JAK3 (0.52) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2696691 | 0.89 | JAK3 (0.60) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2694922 | 0.89 | JAK3 (0.59) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2693142 | 0.88 | JAK3 (0.50) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2697907 | 0.87 | JAK3 (0.58) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2694446 | 0.86 | JAK3 (0.57) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2693078 | 0.85 | JAK3 (0.58) | JAK3IRAK4JAK2JAK1TYK2 | |
| SCHEMBL2697296 | 0.85 | JAK3 (0.57) | JAK3IRAK4JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |