Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.59 |
| ▸ | JAK1 | P23458 | 8/20 | 0.59 |
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.59 |
| ▸ | JAK2 | O60674 | 7/20 | 0.59 |
| ▸ | TYK2 | P29597 | 4/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | CD38 | P28907 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2694880 | 0.89 | JAK3 (0.56) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL2696695 | 0.87 | JAK3 (0.58) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL12321946 | 0.87 | JAK3 (0.62) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL12321939 | 0.86 | JAK3 (0.55) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL2692726 | 0.85 | JAK3 (0.53) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL17322970 | 0.85 | JAK3 (0.52) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL12322720 | 0.84 | STAT6 (0.60) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL12301505 | 0.84 | JAK3 (0.64) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL12321969 | 0.84 | JAK3 (0.51) | JAK3JAK1IRAK4JAK2TYK2 | |
| SCHEMBL12322726 | 0.84 | STAT6 (0.58) | JAK3JAK1IRAK4JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |