Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.33 |
| ▸ | OXTR | P30559 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1288867 | 0.89 | MTOR (0.35) | MTORPIK3CAGAATRPM8NUDT1 | |
| SCHEMBL1688527 | 0.83 | MTOR (0.35) | MTORPIK3CATRPM8NUDT1ATR | |
| SCHEMBL1688532 | 0.76 | GAA (0.34) | MTORGAATRPM8LMNAHTT | |
| SCHEMBL1288910 | 0.76 | MTOR (0.35) | MTORPIK3CAGAATRPM8NUDT1 | |
| SCHEMBL2688281 | 0.76 | GAA (0.34) | MTORGAATRPM8LMNAHTT | |
| SCHEMBL2689714 | 0.75 | MTOR (0.37) | MTORPIK3CAATRATRIP | |
| SCHEMBL1288812 | 0.75 | PLK1 (0.41) | — | |
| SCHEMBL1288808 | 0.75 | PLK1 (0.41) | — | |
| SCHEMBL1288520 | 0.74 | PLK1 (0.42) | — | |
| SCHEMBL1288526 | 0.74 | PLK1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |