Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK2 | Q9NYY3 | 20/20 | 0.46 |
| ▸ | PLK1 | P53350 | 17/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1288499 | 1.00 | PLK2 (0.46) | PLK2PLK1PLK3 | |
| SCHEMBL1688601 | 0.97 | PLK2 (0.46) | PLK2PLK1PLK3 | |
| SCHEMBL2690036 | 0.97 | PLK2 (0.46) | PLK2PLK1PLK3 | |
| SCHEMBL1288889 | 0.97 | PLK2 (0.45) | PLK2PLK1PLK3 | |
| SCHEMBL2688038 | 0.93 | PLK2 (0.39) | PLK2PLK1PLK3 | |
| SCHEMBL2690660 | 0.93 | PLK2 (0.39) | PLK2PLK1PLK3 | |
| SCHEMBL2687954 | 0.91 | PLK2 (0.38) | PLK2PLK1PLK3 | |
| SCHEMBL2689838 | 0.90 | PLK2 (0.38) | PLK2PLK1PLK3 | |
| SCHEMBL1688498 | 0.90 | PLK2 (0.38) | PLK2PLK1PLK3 | |
| SCHEMBL2688989 | 0.90 | PLK2 (0.39) | PLK2PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048129-A2 | INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2012-04-12 | — | — | WO | disclosed |