Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25067601 | 0.83 | ADORA2A (0.41) | HRH4ADORA1ADORA2AADORA3ADORA2B | |
| SCHEMBL26113255 | 0.80 | ADORA2A (0.41) | HRH4ADORA1ADORA2AADORA3ADORA2B | |
| SCHEMBL4364664 | 0.72 | ADORA2A (0.42) | HRH4ADORA1ADORA2AADORA3ADORA2B | |
| SCHEMBL15845707 | 0.70 | ADORA2A (0.44) | HRH4ADORA1ADORA2AADORA3ADORA2B | |
| SCHEMBL20564658 | 0.70 | HRH4 (0.56) | HRH4ADORA1ADORA2ABACE1ENPP3 | |
| SCHEMBL1033638 | 0.69 | HRH4 (1.00) | HRH4 | |
| SCHEMBL31308977 | 0.66 | CYP2A6 (0.40) | LMNAKDM4ECYP2A6CYP17A1ALOX5AP | |
| SCHEMBL22095085 | 0.66 | CYP2A6 (0.40) | LMNAKDM4ECYP2A6CYP17A1ALOX5AP | |
| SCHEMBL21996300 | 0.65 | ADORA2A (0.40) | ADORA1ADORA2AADORA3ADORA2BPDE10A | |
| SCHEMBL823604 | 0.65 | ADORA2A (0.42) | ADORA1ADORA2AADORA3ADORA2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270002-A1 | Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg (NL) | 2011-01-05 | — | — | EP | disclosed |
| WO-2010146173-A1 | QUINAZOLINE DERIVATIVES AS HISTAMINE H4-RECEPT0R INHIBITORS FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS | VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG (NL) | 2010-12-23 | — | — | WO | disclosed |