Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 20/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.58 |
| ▸ | MTOR | P42345 | 5/20 | 0.58 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595465 | 0.80 | ATR (0.66) | ATRPIK3CAMTORPRKDC | |
| SCHEMBL29397370 | 0.80 | ATR (0.66) | ATRPIK3CAMTORPRKDC | |
| SCHEMBL6522212 | 0.77 | ATR (1.00) | ATRPIK3CAMTOR | |
| SCHEMBL1025284 | 0.76 | PIK3CA (0.52) | ATRPIK3CAMTORPRKDC | |
| SCHEMBL3599563 | 0.76 | ATR (0.54) | ATRPIK3CAMTORPRKDC | |
| SCHEMBL3599561 | 0.76 | ATR (0.53) | ATRPIK3CAMTORPRKDC | |
| SCHEMBL3599566 | 0.75 | ATR (0.53) | ATRPIK3CAMTORPRKDC | |
| SCHEMBL2517776 | 0.74 | ATR (1.00) | ATRPIK3CAMTOR | |
| SCHEMBL2516329 | 0.73 | ATR (1.00) | ATRPIK3CAMTOR | |
| SCHEMBL3621445 | 0.72 | PIK3CD (0.69) | PIK3CAMTORPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150546-B1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE | HOFFMANN LA ROCHE (CH) | 2011-01-19 | — | — | EP | disclosed |
| US-20100130496-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130496-A1 | PYRIMIDINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL-3-KINASE | PIK3CA, PIP5K1B, PIK3CD | ATR 453/4885PIK3CA 1/4885MTOR 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.