Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.64 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.59 |
| ▸ | SGK1 | O00141 | 3/20 | 0.56 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857422 | 0.90 | AXL (0.61) | AXLAAK1SGK1CAMKK2CDK8 | |
| SCHEMBL10293346 | 0.88 | BRD4 (0.56) | AXLAAK1PAK1NTRK1CDK2 | |
| SCHEMBL1516774 | 0.85 | AAK1 (0.66) | AXLAAK1SGK1CAMKK2CDK8 | |
| SCHEMBL415002 | 0.83 | AXL (0.69) | AXLAAK1SGK1CAMKK2GSK3B | |
| SCHEMBL878650 | 0.82 | TNIK (0.54) | AXLAAK1CAMKK2TNIKNTRK1 | |
| SCHEMBL857046 | 0.81 | AXL (0.59) | AXLAAK1SGK1CAMKK2CDK8 | |
| SCHEMBL857630 | 0.81 | AXL (0.58) | AXLAAK1SGK1CAMKK2CDK8 | |
| SCHEMBL24296622 | 0.80 | AXL (0.76) | AXLAAK1SGK1CAMKK2CDK8 | |
| SCHEMBL20584650 | 0.80 | AXL (0.71) | AXLAAK1SGK1CAMKK2CDK8 | |
| SCHEMBL414820 | 0.80 | AXL (0.58) | AXLAAK1SGK1CAMKK2CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-20100256365-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256365-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | AXL 1354/4885AAK1 335/4885SGK1 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.