Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1268072 | 0.88 | CLK1 (0.50) | CLK1DYRK1ACDC7CDK2CCNE1 | |
| SCHEMBL878800 | 0.82 | NEK2 (0.57) | DYRK1ACDC7CDK2KDRADORA2A | |
| SCHEMBL858894 | 0.80 | ADORA2A (0.56) | DYRK1ACDC7CDK2DBF4KDR | |
| SCHEMBL415716 | 0.77 | CDC7 (0.62) | CLK1DYRK1ACDC7CDK2CCNE1 | |
| SCHEMBL413384 | 0.77 | TAAR1 (0.53) | CDC7CDK2ROCK2MAP4K4PIM1 | |
| SCHEMBL878912 | 0.76 | CSF1R (0.52) | CDC7CDK2CCNE1DBF4KDR | |
| SCHEMBL1267898 | 0.74 | ADORA2A (0.55) | DYRK1ACDC7CDK2CCNE1DBF4 | |
| SCHEMBL12772764 | 0.74 | MAP2K1 (0.58) | CLK1DYRK1ACDC7CDK2CCNE1 | |
| SCHEMBL878719 | 0.74 | MAP2K1 (0.61) | CDK2CCNE1KDRADORA2ANEK2 | |
| SCHEMBL414293 | 0.74 | BRAF (0.55) | CLK1DYRK1AROCK2NEK2MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |