Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10003233 | 0.94 | SMO (0.52) | SMOCTSSEPHX2JAK2JAK1 | |
| SCHEMBL10003710 | 0.94 | SMO (0.52) | SMOCTSSEPHX2SSTR5 | |
| SCHEMBL10003287 | 0.94 | SMO (0.52) | SMOCTSSEPHX2JAK2JAK1 | |
| SCHEMBL10004388 | 0.94 | SMO (0.52) | SMOEPHX2SSTR5 | |
| SCHEMBL10003802 | 0.93 | SMO (0.51) | SMOEPHX2SYKENPP2 | |
| SCHEMBL10004015 | 0.93 | SMO (0.57) | SMOEPHX2JAK2JAK1JAK3 | |
| SCHEMBL10003168 | 0.93 | SMO (0.51) | SMOEPHX2HPGDS | |
| SCHEMBL10003362 | 0.93 | SMO (0.52) | SMOEPHX2JAK2JAK1JAK3 | |
| SCHEMBL10003509 | 0.92 | SMO (0.50) | SMOCTSSJAK2JAK1JAK3 | |
| SCHEMBL10003708 | 0.91 | SMO (0.53) | SMOEPHX2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471789-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-07-04 | — | — | EP | disclosed |