Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12824853 | 0.83 | SMO (0.39) | SMOEPHX2JAK2JAK1JAK3 | |
| SCHEMBL10002926 | 0.79 | SMO (0.51) | SMOEPHX2 | |
| SCHEMBL10003421 | 0.78 | SMO (0.49) | SMO | |
| SCHEMBL10003187 | 0.78 | SMO (0.54) | SMOEPHX2 | |
| SCHEMBL10003592 | 0.77 | SMO (0.59) | SMOEPHX2 | |
| SCHEMBL10003363 | 0.77 | SMO (0.52) | SMOEPHX2 | |
| SCHEMBL10003350 | 0.76 | SMO (0.51) | SMOEPHX2 | |
| SCHEMBL10003279 | 0.76 | SMO (0.53) | SMOEPHX2 | |
| SCHEMBL10003696 | 0.76 | SMO (0.48) | SMOEPHX2 | |
| SCHEMBL10003040 | 0.76 | SMO (0.47) | SMOEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471789-A1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-07-04 | — | — | EP | disclosed |