Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 5/20 | 0.51 |
| ▸ | PDE4A | P27815 | 3/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029900 | 1.00 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CCA1 | |
| SCHEMBL1027617 | 0.90 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL1027619 | 0.90 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL1027012 | 0.85 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL1030403 | 0.85 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL1027013 | 0.85 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CSMN1; SMN2 | |
| SCHEMBL1027684 | 0.85 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL3193286 | 0.82 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL4885939 | 0.82 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1030398 | 0.81 | PDE4B (0.77) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044023-B1 | DERIVATIVES OF 1-PHENYL-2-PYRIDYNYL ALKYLENE ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS | CHIESI FARMA SPA (IT) | 2011-01-19 | — | — | EP | disclosed |