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SCHEMBL10299792

SCHEMBL10299792

COC(=O)c1ccc(NC(=O)[C@@H]2N[C@H](CC(C)(C)C)[C@]3(C(=O)Nc4c3ccc(Cl)c4F)[C@H]2c2cccc(Cl)c2F)c(OC)c1

nearest known ligand 0.88

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ MDM2 Q00987 20/20 0.88
▸ TP53 P04637 3/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12102710 1.00 MDM2 (0.88) MDM2TP53
SCHEMBL222462 0.94 MDM2 (1.00) MDM2TP53
SCHEMBL1957635 0.94 MDM2 (1.00) MDM2TP53
SCHEMBL10299791 0.90 MDM2 (0.90) MDM2TP53
SCHEMBL29776561 0.90 MDM2 (0.90) MDM2TP53
SCHEMBL222465 0.90 MDM2 (0.90) MDM2TP53
SCHEMBL222464 0.90 MDM2 (0.90) MDM2TP53
SCHEMBL223159 0.89 MDM2 (0.79) MDM2TP53
SCHEMBL223158 0.89 MDM2 (0.79) MDM2TP53
SCHEMBL1955534 0.89 MDM2 (0.79) MDM2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8217044-B2 Spiroindolinone pyrrolidines HOFFMANN-LA ROCHE INC. (US) 2012-07-10 — — US disclosed
US-8217044-B2 Spiroindolinone pyrrolidines HOFFMANN-LA ROCHE INC. (US) 2012-07-10 — — US disclosed
WO-2011134925-A1 SPIROINDOLINONE PYRROLIDINES F. HOFFMANN-LA ROCHE AG (CH) 2011-11-03 — — WO disclosed