Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 8/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14390395 | 0.86 | HDAC8 (0.67) | DPP4HDAC8DPP7 | |
| SCHEMBL15382612 | 0.84 | DPP4 (0.57) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL18492870 | 0.84 | DPP4 (0.64) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL23211269 | 0.84 | DPP4 (0.57) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL3136106 | 0.84 | DPP4 (0.64) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL1040335 | 0.84 | HDAC8 (0.69) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL368452 | 0.84 | HDAC8 (0.69) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL1619160 | 0.84 | HDAC8 (0.69) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL23211353 | 0.83 | DPP7 (0.56) | DPP4HDAC8DPP7AKT1DPP8 | |
| SCHEMBL23211354 | 0.83 | DPP7 (0.56) | DPP4HDAC8DPP7AKT1DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474534-A1 | 3-Aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immunostimulant activity | Allergan, Inc. (US) | 2012-07-11 | — | — | EP | disclosed |
| US-7635775-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635775-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |
| US-7183281-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183281-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-27 | — | — | US | disclosed |