Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4543678 | 0.89 | OPRL1 (0.46) | GRM2OPRL1TP53HTR2AHTR2C | |
| SCHEMBL1782899 | 0.82 | TP53 (0.44) | GRM2OPRL1HCAR2TP53HTR2A | |
| SCHEMBL10306260 | 0.79 | OPRL1 (0.40) | GRM2OPRL1HCAR2HTR2AHTR2C | |
| SCHEMBL12539971 | 0.79 | HCAR2 (0.48) | GRM2HCAR2TP53 | |
| SCHEMBL12539973 | 0.79 | HCAR2 (0.48) | GRM2HCAR2TP53 | |
| SCHEMBL12541089 | 0.79 | HCAR2 (0.48) | GRM2HCAR2TP53 | |
| SCHEMBL9731852 | 0.78 | KDM1A (0.45) | HCAR2 | |
| SCHEMBL434354 | 0.77 | OPRL1 (0.57) | GRM2OPRL1HTR2AHTR2CHTR2B | |
| SCHEMBL12541069 | 0.76 | PDE4A (0.43) | GRM2HCAR2HTR2AHTR2CHTR2B | |
| SCHEMBL12540090 | 0.76 | PDE4A (0.43) | GRM2HCAR2HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940401-B1 | ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MERCK SHARP & DOHME (US) | 2012-07-11 | — | — | EP | disclosed |
| WO-2007047496-A2 | ACYLATED SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-04-26 | — | — | WO | disclosed |