Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.68 |
| ▸ | KIT | P10721 | 3/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1030943 | 0.86 | PDGFRB (0.60) | PDGFRBKITPDGFRAFLT3TRPV1 | |
| SCHEMBL7666887 | 0.85 | PDGFRB (0.70) | PDGFRBKITPDGFRAFLT3TRPV1 | |
| SCHEMBL1030346 | 0.83 | PDGFRB (0.69) | PDGFRBKITPDGFRAFLT3MAPT | |
| SCHEMBL2297686 | 0.82 | HTT (0.67) | MAPTMAPK1HTTHRH4TP53 | |
| SCHEMBL1028741 | 0.81 | PDGFRB (1.00) | PDGFRBKITPDGFRAFLT3 | |
| SCHEMBL1031646 | 0.80 | PDGFRB (0.75) | PDGFRBKITFLT3MAPT | |
| SCHEMBL2922171 | 0.78 | PDGFRB (0.73) | PDGFRBKITPDGFRAFLT3TRPV1 | |
| SCHEMBL7666881 | 0.77 | TRPV1 (0.53) | PDGFRBKITPDGFRAFLT3TRPV1 | |
| SCHEMBL28813844 | 0.76 | GAA (0.85) | TRPV1GAAMAPTMAPK1KDM4E | |
| SCHEMBL2920567 | 0.75 | PDGFRB (0.74) | PDGFRBKITPDGFRAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067123-B1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-01-19 | — | — | EP | disclosed |
| US-6423716-B1 | Nitrogenous heterocyclic compounds | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2002-07-23 | — | — | US | disclosed |
| EP-1067123-A1 | NITROGENOUS HETEROCYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-01-10 | — | — | EP | disclosed |