Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 15/20 | 0.56 |
| ▸ | KDR | P35968 | 12/20 | 0.56 |
| ▸ | INSR | P06213 | 3/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1185179 | 0.87 | PLK1 (0.58) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1183158 | 0.82 | KDR (0.77) | PLK1KDRINSR | |
| SCHEMBL12888864 | 0.79 | PLK1 (0.65) | PLK1KDR | |
| SCHEMBL1185109 | 0.77 | PLK1 (0.54) | PLK1KDRINSR | |
| SCHEMBL1185163 | 0.77 | PLK1 (0.86) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL1183950 | 0.75 | PLK1 (0.60) | PLK1KDRINSR | |
| SCHEMBL1184235 | 0.75 | KDR (0.62) | PLK1KDRINSRPTK2AURKB | |
| SCHEMBL13998729 | 0.75 | PLK1 (0.75) | PLK1KDR | |
| SCHEMBL1185433 | 0.74 | PLK1 (0.74) | PLK1KDR | |
| SCHEMBL10310022 | 0.74 | PLK1 (0.51) | PLK1KDRINSRPTK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178739-A1 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-07-12 | — | — | US | disclosed |
| US-20110039820-A1 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178739-A1 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | PRKCI, PIK3CA, AKT1 | PLK1 69/4885KDR 3047/4885INSR 2130/4885 |
| US-20110039820-A1 | LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | PRKCI, PIK3CA, AKT1 | PLK1 69/4885KDR 3047/4885INSR 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.