Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.33 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 3/20 | 0.32 |
| ▸ | GRK6 | P43250 | 4/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10312078 | 0.90 | DHODH (0.41) | MELKL3MBTL1HRH4KCNH3HDAC4 | |
| SCHEMBL10312137 | 0.87 | GRK6 (0.36) | HRH4GRK6AURKA | |
| SCHEMBL10312185 | 0.86 | NTRK1 (0.47) | — | |
| SCHEMBL10312133 | 0.86 | NTRK1 (0.39) | L3MBTL1HRH4KCNH3NFE2L2IDH2 | |
| SCHEMBL10312129 | 0.80 | KDM4E (0.41) | IDH2 | |
| SCHEMBL10312126 | 0.80 | IDH2 (0.47) | MELKHRH4NFE2L2IDH2 | |
| SCHEMBL10312151 | 0.80 | HRH4 (0.49) | HRH4IDH2AURKA | |
| SCHEMBL10312218 | 0.79 | NTRK1 (0.44) | GRK6AURKA | |
| SCHEMBL10312029 | 0.78 | HDAC4 (0.37) | MELKL3MBTL1HRH4IDH1KCNH3 | |
| SCHEMBL10312098 | 0.78 | IDH2 (0.37) | L3MBTL1HRH4NFE2L2IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178758-A1 | STYRYL-TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | CALIFORNIA CAPITAL EQUITY, LLC (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178758-A1 | STYRYL-TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS | STK25, STK35, SGK2 | MELK 169/4885L3MBTL1 1508/4885HRH4 2393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.