Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10277389 | 0.94 | GRM5 (0.64) | GRM5 | |
| SCHEMBL10312988 | 0.90 | GRM5 (0.55) | GRM5 | |
| SCHEMBL10312985 | 0.90 | KCNA5 (0.48) | GRM5ALDH1A1 | |
| SCHEMBL10277236 | 0.86 | GRM5 (0.56) | GRM5 | |
| SCHEMBL10277477 | 0.85 | GRM5 (0.59) | GRM5 | |
| SCHEMBL10313097 | 0.82 | PTGS1 (0.51) | GRM5ALDH1A1 | |
| SCHEMBL10312989 | 0.79 | GRM5 (0.56) | GRM5ALDH1A1 | |
| SCHEMBL10277026 | 0.76 | HSP90AB1 (0.53) | GRM5 | |
| SCHEMBL10313047 | 0.74 | PTGS1 (0.51) | GRM5ALDH1A1 | |
| SCHEMBL13968464 | 0.74 | GRM5 (0.87) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178776-A1 | DIHYDRONAPHTHYRIDINYL(ORGANO)METHANONE ANALOGS AS POSITIVE ALLOSTERIC MGLUR5 MODULATORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178776-A1 | DIHYDRONAPHTHYRIDINYL(ORGANO)METHANONE ANALOGS AS POSITIVE ALLOSTERIC MGLUR5 MODULATORS | GRM5, GRIK5, GRM3 | GRM5 1/4885ALDH1A1 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.