Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15653580 | 0.91 | TSHR (0.34) | TSHR | |
| SCHEMBL10857190 | 0.86 | TSHR (0.31) | TSHR | |
| SCHEMBL9802582 | 0.85 | TSHR (0.32) | TSHRBIRC2 | |
| SCHEMBL16157239 | 0.85 | GAA (0.36) | TSHR | |
| SCHEMBL4135098 | 0.85 | TSHR (0.30) | TSHR | |
| SCHEMBL15966868 | 0.85 | MGAM (0.36) | TSHR | |
| SCHEMBL8194318 | 0.85 | TSHR (0.32) | TSHRBIRC2 | |
| SCHEMBL4135094 | 0.85 | TSHR (0.30) | TSHR | |
| SCHEMBL10858660 | 0.85 | TSHR (0.30) | TSHR | |
| SCHEMBL15966867 | 0.85 | MGAM (0.36) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933195-B2 | Histone deacetylase inhibitors and synthetic method thereof and use thereof in manufacture of medicaments | NANJING YOKO BIOMEDICAL R & D LTD. (CN) | 2015-01-13 | — | — | US | disclosed |
| US-20140243501-A1 | HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS | NANJING YOKO BIOMEDICAL R & D LTD. [CN/CN] (CN) | 2014-08-28 | — | — | US | disclosed |
| US-8791144-B2 | Substituted N-phenyl-1-(4-Pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-29 | — | — | US | disclosed |
| US-8258321-B2 | Beta-lactone compounds | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2012-09-04 | — | — | US | disclosed |
| US-20120172354-A1 | Substituted N-Phenyl-1-(4-Pyridinyl)-1H-Pyrazol-3-Amines | JANSSEN PHARMACEUTICA NV (BE) | 2012-07-05 | — | — | US | disclosed |
| US-20090124681-A1 | BETA-LACTONE COMPOUNDS | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124681-A1 | BETA-LACTONE COMPOUNDS | LBR, CYP8B1, GLB1 | TSHR 264/4885BIRC2 1244/4885CA1 1772/4885 |
| US-20140243501-A1 | HISTONE DEACETYLASE INHIBITORS AND SYNTHETIC METHOD THEREOF AND USE THEREOF IN MANUFACTURE OF MEDICAMENTS | HDAC1, HDAC11, HDAC2 | TSHR 1488/4885BIRC2 4263/4885CA1 893/4885 |
| US-20120172354-A1 | Substituted N-Phenyl-1-(4-Pyridinyl)-1H-Pyrazol-3-Amines | CHRM1, CHRNA1, CHRM3 | TSHR 82/4885BIRC2 4540/4885CA1 4471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.