Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 7/20 | 0.58 |
| ▸ | PGR | P06401 | 4/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590938 | 0.91 | AXL (0.63) | AXLPGRNR3C1ARESR2 | |
| SCHEMBL10317862 | 0.85 | AXL (0.62) | AXLBRAFMAPK14 | |
| SCHEMBL1591670 | 0.85 | AXL (0.49) | AXLPGRNR3C1ARESR2 | |
| SCHEMBL1591266 | 0.85 | AXL (0.59) | AXLPGRKEAP1NFE2L2 | |
| SCHEMBL1591689 | 0.80 | AXL (0.53) | AXLPGR | |
| SCHEMBL1591628 | 0.78 | AXL (0.50) | AXLBRAFMAPK14 | |
| SCHEMBL1591383 | 0.78 | AXL (0.48) | AXLPTGES2 | |
| SCHEMBL1590968 | 0.77 | AXL (0.49) | AXL | |
| SCHEMBL1592031 | 0.75 | AXL (0.47) | AXL | |
| SCHEMBL1591224 | 0.75 | FFAR1 (0.56) | PGRNR3C1ARESR2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262772-B1 | QUINOLINE DERIVATIVES AS AXL KINASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2012-07-18 | — | — | EP | claimed |