Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | CD44 | P16070 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | PRCP | P42785 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | DRD5 | P21918 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10320905 | 0.82 | HTR2C (0.52) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL10321000 | 0.82 | MAOB (0.46) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL10321123 | 0.70 | TSHR (0.48) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL10320500 | 0.70 | TSHR (0.48) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL4166749 | 0.69 | TSHR (0.53) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL175146 | 0.69 | HTR2C (1.00) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL2998 | 0.68 | HTR2C (0.46) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL2203 | 0.68 | NPC1 (0.42) | HTR2CMAOBPNMTCD44TSHR | |
| SCHEMBL23555058 | 0.67 | HTR2C (0.94) | HTR2CMAOBPNMTCD44TSHR | |
| Ammonia Solution, Strong SCHEMBL20359164 | 0.67 | HTR2C (0.94) | HTR2CMAOBPNMTCD44TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951046-B1 | METHODS TO ENHANCE CHEMOTHERAPY | GENZYME CORP (US) | 2012-07-18 | — | — | EP | claimed |