Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.77 |
| ▸ | DYRK1B | Q9Y463 | 16/20 | 0.72 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322896 | 0.96 | DYRK1A (0.77) | DYRK1ADYRK1B | |
| SCHEMBL10323589 | 0.95 | DYRK1A (0.80) | DYRK1ADYRK1BFGFR1 | |
| SCHEMBL10448263 | 0.95 | DYRK1A (0.69) | DYRK1ADYRK1BFGFR1 | |
| SCHEMBL11952856 | 0.94 | DYRK1A (0.76) | DYRK1ADYRK1B | |
| SCHEMBL10324489 | 0.92 | DYRK1A (0.84) | DYRK1ADYRK1B | |
| SCHEMBL10324061 | 0.91 | DYRK1A (0.80) | DYRK1ADYRK1B | |
| SCHEMBL11950642 | 0.91 | DYRK1A (0.75) | DYRK1ADYRK1B | |
| SCHEMBL10324109 | 0.89 | DYRK1A (0.83) | DYRK1ADYRK1B | |
| SCHEMBL10323587 | 0.89 | DYRK1A (0.90) | DYRK1ADYRK1B | |
| SCHEMBL10323857 | 0.88 | DYRK1A (0.87) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184542-A1 | PYRIDO PYRIMIDINES | ANDERSON KEVIN (US) | 2012-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120184542-A1 | PYRIDO PYRIMIDINES | TYMS, TYMP, DPYD | DYRK1A 654/4885DYRK1B 570/4885FGFR1 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.